Association Between Stroke and Adrenal Incidentalomas (ABSAI)

  • STATUS
    Recruiting
  • End date
    Feb 28, 2029
  • participants needed
    2
  • sponsor
    Xuanwu Hospital, Beijing
Updated on 21 March 2022

Summary

Adrenal incidentalomas (AIs) are commonly encountered in transsection imaging which purpose not for suspected adrenal disease. However, part of AIs in patients is associated with Stroke. Stroke is a diseases which could cause of disability and death worldwide. In clinical practice, detailed information about the association between stroke and AIs is not available. In this study, the investigators aimed to investigate the risk for disability and death in the large group of stroke patients with AIs.

Description

Background

Adrenal incidentalomas (AIs) are commonly encountered in transsection imaging which purpose not for suspected adrenal disease. However, part of AIs in patients is associated with Stroke . The investigators aimed to investigate the risk for disability and death in the large group of stroke patients with AIs.

Objective

To measure the association between stroke and levels of autonomous cortisol secretion in patients with AIs.

Design

Part 1, Retrospective cohort study.

From April 1, 2021, to September 30, 2021, cohort patients with stroke were recruited in this study. The investigators assess the standardised incidence rate of AIs in all patients. Meanwhile, detail information about stroke disease、patient and AIs characteristics were record.

Part 2, Prospective cohort study.

From Mar 1, 2022, to Feb 29, 2024, cohort patients with stroke plane to recruit in this study. All patient receive the plasma cortisol level after a 1-mg dexamethasone suppression test. The investigators assess the standardised incidence rate of AIs in all patients. Meanwhile, detail information about stroke disease、patient and AIs characteristics would be record.

Details
Condition Stroke, Adrenal Incidentaloma
Clinical Study IdentifierNCT05237817
SponsorXuanwu Hospital, Beijing
Last Modified on21 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

stroke disease , such as Cerebral infarction、Intracerebral hemorrhage and Subarachnoid hemorrhage

Exclusion Criteria

presence of metastatic cancer
AIs smaller than 1 cm
nonadenoma lesions, such as myelolipomas,hemorrhages, and cysts
oral glucocorticoid treatment with more than single doses in the past 3 months
use of inhaled steroids or medication affecting dexamethasone metabolism
systemic estrogen treatment
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