Role of Slow Waves and Sleep Apnea in Memory and Risk for Alzheimer's Disease

  • STATUS
    Recruiting
  • End date
    Sep 4, 2025
Updated on 25 March 2022

Summary

Untreated sleep apnea (short episodes of stopping breathing) is thought to contribute to difficulty with memory. The purpose of this study is determining what effects sleep apnea has on the specific ability to remember locations and as well as on proteins in your body that contribute to risk for Alzheimer disease, a disorder in which memory loss is a main feature.
You may qualify to take part in this research study because you have severe sleep apnea and have proven that you have used your CPAP (Continuous Positive Airway Pressure) machine consistently over the last two (2) months.

Description

Untreated sleep apnea (short episodes of stopping breathing) is thought to contribute to difficulty with memory. The purpose of this study is determining what effects sleep apnea has on the specific ability to remember locations and as well as on proteins in your body that contribute to risk for Alzheimer disease, a disorder in which memory loss is a main feature. Visit 1: About Thirty (30) Minutes. During this visit:  A review of CPAP adherence will be done in order to ensure minimum required adherence.  A review of current medications to determine if they may act as confounders.  You will be consented (only if you were not consented during your clinical visit).  Your height and weight will be measured.  You will be given an assessment that will measure cognitive function.  You will fill out a video game experience questionnaire.  You will receive an actigraphy to wear for two weeks and a sleep diary.  You will be scheduled for a brain MRI. Visit 2: About Forty-Five (45) Minutes. During this visit:  You will have a brain MRI.This scan will be obtained prior to the collection of spinal fluid to determine any reasons that would compromise the safety of collecting the spinal fluid. Additionally we will collect information about the sizes of different parts of the brain. Visits 3-5: During your overnight sleep studies, one of 3 conditions will occur: 1) You will sleep through the night with your known therapeutic CPAP pressure. 2) CPAP pressure will be reduced during sleep in a stage-specific manner and will be returned to the therapeutic level when you exit that stage. It is estimated that CPAP will be reduced for 5- 40% of sleep. 3) CPAP pressure will be reduced and supplemental oxygen will be given during sleep in a stage-specific manner. CPAP will be returned to the therapeutic level and supplemental oxygen will be discontinued when you exit that stage. It is estimated that CPAP will be reduced and supplemental oxygen supplied for 5-40% of sleep. Each successive night of study will occur roughly 1-2 weeks after the prior night of study. The order of conditions across the three nights will be random, and you will experience all 3 distinct conditions. Please make sure that someone (i.e. a family member, friend, or partner) can be available to accompany you home after the testing, if need be.

Details
Condition Alzheimer's Disease, obstructive sleep apnea, OSA, CPAP, slow wave sleep, SWS, continuous positive airway pressure treatment
Clinical Study IdentifierTX291190
Last Modified on25 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Adult subjects (ages 25-85) with previously diagnosed severe obstructive sleep apnea (AHI4%>20/hour), who have been on CPAP therapy for at least 2 months and have documented good adherence at a therapeutic CPAP pressure will be approached for participation in the study with the expectation that 15 may drop out
Adherence will be confirmed through data downloads from each patient's home CPAP machine
Appropriate compliance will be defined as #4 hours usage per night for #70% of nights (the current Medicare CPAP compliance criteria)

Exclusion Criteria

chronic use of any sedative, stimulant, or neuroleptic drugs, the presence of critical comorbid conditions, such as class III-IV heart failure or lung disease requiring supplemental oxygen, preexisting cognitive or neurological deficits
Anyone with contraindication to the medical procedures is excluded
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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