Effect of Exercise on Biomarkers in SCT

  • days left to enroll
  • participants needed
  • sponsor
    St. Louis University
Updated on 22 March 2022
sickle cell trait
Accepts healthy volunteers


This study measures the effect of exercise on a variety of biomarkers in blood and urine selected to evaluate the physiological pathways of hemolysis, myolysis, thrombosis, inflammation, and renal function in subjects with sickle cell trait. These pathways have been shown to be associated with adverse events in athletes and warfighters with SCT upon protracted, repeated, strenuous exertion. Changes in biomarkers post-exercise compared to pre-exercise (and compared to healthy controls) suggest activation of the associated pathway(s) which may contribute to exercise-related events in athletes and warfighters and subclinical complications in non-athletes.


Subjects with sickle cell trait and healthy controls will be subjected to a single bout of moderate, controlled exercise on a treadmill. Blood and urine samples will be collected before exercise, immediately after exercise, and 24 hours after exercise. Fifteen biomarkers, three selected to evaluate each of the five physiologic pathways previously listed, will be tested at each of the three time points. Abnormal biomarkers before exercise suggest chronic pathway activation while exacerbated levels after exercise suggest further activation stimulated by exercise. Biomarker levels 24 hours post-exercise will be used to evaluate continued pathway activation or pathway recovery. By definition, 95% of health controls will show normal biomarker levels pre-exercise and biomarker patterns post-exercise will serve as the expected standard by which to compare the test subjects.

Condition Sickle Cell Trait
Treatment Exercise
Clinical Study IdentifierNCT04273022
SponsorSt. Louis University
Last Modified on22 March 2022


Yes No Not Sure

Inclusion Criteria

Sickle Cell Trait Group (AS)
Health subjects with sickle cell trait (AS)
Ages 18-70 years
Inclusion Criteria: Control group (AA)
Healthy subjects without sickle cell trait (AA)
Ages 18-70 years

Exclusion Criteria

Sickle Cell Trait group (AS) AND healthy controls (AA)
Subjects will be excluded if they
weigh less than 110 pounds
are pregnant
have hemoglobinopathies (other than sickle cell trait) as determined by Hb electrophoresis
have other self-reported conditions known to cause blood coagulation activation, myocyte destruction, hemolysis, chronic inflammation, or renal disease
any condition that places subjects at risk during exercise
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