14-day PCAB-based High-dose Dual Therapy and14-day PCAB-based Triple Therapy vs 14-day PPI-based Reverse Hybrid Therapy
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- STATUS
- Recruiting
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- End date
- Dec 31, 2024
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- participants needed
- 906
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- sponsor
- Kaohsiung Medical University
Summary
- Test for Helicobacter pylori. The test items include urease test, histology, bacterial culture, serology, and urea breath test. At least two positive results can be used to confirm the diagnosis.
- To ensure that the research results are not artificially distorted, this trial is a randomized study. Random allocation (which means that the subjects will use the "random number table generated by a computer similar to the lottery" to determine the treatment group) accept one of the following schemes (1:1:1).
Description
Helicobacter pylori (H.pylori) infect more than 50% of humans globally. This study were (1) to test whether the efficacies of 14-day PCAB-based high-dose dual therapy and 14-day PPI-based reverse hybrid therapy can achieve a higher eradication rate than 14-day PCAB-based triple therapy in the first-line treatment of H pylori infection, (2) to compare the eradication rates of 14-day PCAB-based and PPI-based bismuth quadruple therapies in the second-line treatment of H pylori infection, and (3) to examine the impacts of antibiotic resistance of H pylori as well as CYP3A4, CYP2C19 and IL-1B -511 genotypes of host on the eradication efficacies of anti-H pylori treatments.
Details
| Condition | Helicobacter Pylori Eradication |
|---|---|
| Treatment | Vonoprazan and Amoxicillin, Vonoprazan, Amoxicillin and Clarithromycin, Rabeprazole, Amoxicillin, Clarithromycin and Metronidazole |
| Clinical Study Identifier | NCT05191888 |
| Sponsor | Kaohsiung Medical University |
| Last Modified on | 23 March 2022 |
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