A Clinical Trial of TAA06 Injection in Advanced Solid Tumors

  • End date
    Dec 1, 2023
  • participants needed
  • sponsor
    PersonGen BioTherapeutics (Suzhou) Co., Ltd.
Updated on 24 March 2022


B7-H3 (also known as CD276) is widely expressed on the surface of a variety of malignancies solid tumors, while it rarely or even doesn't express on normal tissues. Therefore, B7-H3 is an ideal target for chimeric antigen receptor (CAR) T cells therapy. TAA06 injection is a CAR T injection targeting B7-H3. This is a phase I clinical study with the primary objective of evaluating the safety and tolerability of TAA06 injection in subjects with TAA06-positive advanced solid tumors. The secondary objectives are as follows: to evaluate the distribution, proliferation and persistence of B7-H3-targeted CAR T cells after injection of TAA06 in subjects; to preliminarily evaluate the efficacy of TAA06 injection in subjects with TAA06-positive advanced solid tumor.

Condition Malignant Melanoma, Lung Cancer, or Colorectal Cancer
Treatment TAA06 injection
Clinical Study IdentifierNCT05190185
SponsorPersonGen BioTherapeutics (Suzhou) Co., Ltd.
Last Modified on24 March 2022


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