A Clinical Trial of TAA06 Injection in Advanced Solid Tumors
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- STATUS
- Recruiting
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- End date
- Dec 1, 2023
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- participants needed
- 18
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- sponsor
- PersonGen BioTherapeutics (Suzhou) Co., Ltd.
Summary
B7-H3 (also known as CD276) is widely expressed on the surface of a variety of malignancies solid tumors, while it rarely or even doesn't express on normal tissues. Therefore, B7-H3 is an ideal target for chimeric antigen receptor (CAR) T cells therapy. TAA06 injection is a CAR T injection targeting B7-H3. This is a phase I clinical study with the primary objective of evaluating the safety and tolerability of TAA06 injection in subjects with TAA06-positive advanced solid tumors. The secondary objectives are as follows: to evaluate the distribution, proliferation and persistence of B7-H3-targeted CAR T cells after injection of TAA06 in subjects; to preliminarily evaluate the efficacy of TAA06 injection in subjects with TAA06-positive advanced solid tumor.
Details
| Condition | Malignant Melanoma, Lung Cancer, or Colorectal Cancer |
|---|---|
| Treatment | TAA06 injection |
| Clinical Study Identifier | NCT05190185 |
| Sponsor | PersonGen BioTherapeutics (Suzhou) Co., Ltd. |
| Last Modified on | 24 March 2022 |
Eligibility
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