Effects of Epalrestat on Peripheral Neuropathy and Central Nervous System in Diabetic Patients

  • End date
    Oct 23, 2023
  • participants needed
  • sponsor
    Xiangya Hospital of Central South University
Updated on 23 March 2022
hemoglobin a1c
hypoglycemic agents


This study evaluated the efficacy of epalrestat in diabetic peripheral neuropathy and its effects on the central nervous system in diabetic peripheral neuropathy subjects.

Condition Diabetes
Treatment Epalrestat,Mecobalamin, Mecobalamin, Mecobalamin
Clinical Study IdentifierNCT05184049
SponsorXiangya Hospital of Central South University
Last Modified on23 March 2022


Yes No Not Sure

Inclusion Criteria

Patients aged 18 to 65 years (to the date of screening);
A clear history of type 2 diabetes (using the 1999 WHO diabetes diagnostic criteria) with a course of disease > 6 months
HbA1c < 7%
Two or more of the following five tests are abnormal: abnormal temperature perception; Nylon wire for hypoesthesia or disappearance of the foot; Abnormal vibration sense; Ankle reflex disappeared; Two or more nerve conduction velocities were reduced
Have not used mecobalamin, epalrestat, lipoic acid or high-dose glucocorticoid in the recent (3 months) period, or have not been involved in other treatment of the same disease within 3 months prior to the study

Exclusion Criteria

Neuropathy caused by other causes, such as cervical and lumbar lesions, cerebral infarction, etc
With acute metabolic complications of diabetes, such as ketoacidosis, lactic acidosis, diabetes hyperotonic state, etc
Severe cardiovascular and cerebrovascular diseases , pulmonary heart disease or pulmonary insufficiency, renal failure, severe dyslipidemia, poorly controlled hypertension, severe hepatitis
Those with a history of malignant tumor or wasting diseases such as tuberculosis
Contraindications to MRI scanning: such as internal (especially oral) metal implants, claustrophobia, etc
Poor compliance or serious side effects
pregnant female
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