SARS-CoV-2 CTLS for Mild to Moderate COVID-19 Disease

  • End date
    Dec 31, 2025
  • participants needed
  • sponsor
    New York Medical College
Updated on 24 March 2022


The 2019 Severe Acute Respiratory Syndrome (SARS) is a global pandemic secondary to a novel coronavirus - SARS-CoV-2. The reported case-fatality ratio for SARS-CoV-2 in the United States is 1.8% with a current death toll of >300,000 and climbing.4 There is no accepted standard of care or FDA approved therapies for treatment of COVID-19. Virus specific cytotoxic T lymphocytes (CTLs) have become an important part of the treatment landscape for viral reactivation post hematopoietic and solid organ transplantation. Donor derived CTLs have been shown to be safe and effective against a variety of viruses including CMV, EBV, BK and adenovirus. We hypothesize that SARS-CoV-2 specific CTLs generated from a previously infected family donor will be safe and effective for treatment of COVID-19 in family members with mild to moderate disease.

Condition Covid19
Treatment Standard of Care, SARS-CoV2-CTLS
Clinical Study IdentifierNCT04896606
SponsorNew York Medical College
Last Modified on24 March 2022


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