DLSCT for Breast Cancer Detection in Women With Dense Breasts (DECREAS)

  • End date
    Jan 1, 2023
  • participants needed
  • sponsor
    Rijnstate Hospital
Updated on 23 March 2022


The main objective of this project is to demonstrate the feasibility of DLSCT to detect breast cancer in women with dense breasts.

Patients with locoregional advanced primary breast cancer and heterogeneously (n = 7) or extremely dense breasts (n = 7) as determined by mammography will be included in this study. These patients have an indication for a positron emission tomography computed tomography (PET-CT) scan to search for distant metastases. In this study the participants will undergo an additional contrast enhanced DLSCT scan to determine the feasibility of spectral CT to detect breast cancer in women with dense breasts.

Condition Breast Neoplasms, Breast Density, Radiographic Image Interpretation, Computer-Assisted
Treatment Dual-layer spectral computerized tomography (DLSCT)
Clinical Study IdentifierNCT05181059
SponsorRijnstate Hospital
Last Modified on23 March 2022


Yes No Not Sure

Inclusion Criteria

Diagnosis of histopathologically proven locoregional advanced primary breast cancer
Tumors > 5 cm (= T3) or
Tumors with invasion of the skin or chest wall (= T4) or
Any tumor with ≥ 4 axillary lymph nodes or ipsilateral internal mammary, infraclavicular or supraclavicular nodal involvement (= N2-3)
Heterogeneously or extremely dense breasts as described by visual assessment on
full-field digital mammograms: category C or D according to the ACR BI-RADS

Exclusion Criteria

History of allergic reactions to iodinated contrast agents
Pregnancy or breast feeding
Treatment of thyroid disease with radioactive iodine
Use of metformin
Creatinine clearance < 45 ml/min
Chronic or acutely worsening renal disease
Patients who are declared incompetent
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