• sponsor
    Alnylam Pharmaceuticals
Updated on 18 April 2022


The purpose of this study is to evaluate the effect of zilebesiran on systolic and diastolic blood pressure and to characterize the pharmacodynamic (PD) effects and safety of zilebesiran as add-on therapy.


  • Condition: Hypertension
  • Clinical Trial Identifier: NCT05103332
  • Sponsor: Alnylam Pharmaceuticals
Looking for participants within a 30 mile radius of the study site.

Condition High Blood Pressure (Hypertension)
Clinical Study IdentifierTX290671
SponsorAlnylam Pharmaceuticals
Last Modified on18 April 2022


Yes No Not Sure

Inclusion Criteria

Age 18 to 75 years
Office SBP at Screening as follows: a.) ≥155 mmHg and ≤180 mmHg for patients with untreated hypertension; b.) ≥145 mmHg and ≤180 mmHg for patients on antihypertensive medications; c.) 24-hour mean SBP >130 mmHg and ≤160 mmHg by ABPM after at least 4 weeks of run-in on protocol-specified background antihypertensive medication

Exclusion Criteria

Secondary hypertension, orthostatic hypotension
Received an investigational agent within the last 30 days
Type 1 diabetes mellitus, poorly controlled Type 2 diabetes mellitus, newly diagnosed Type 2 diabetes mellitus
History of any cardiovascular event within 6 months prior to randomization
History of intolerance to SC injection(s)
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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