The Effect of Menstrual Cycle Phase and a Protein-polyphenol Drink on Muscle Protein Synthesis

  • End date
    Dec 31, 2023
  • participants needed
  • sponsor
    University of Exeter
Updated on 20 June 2022
Accepts healthy volunteers


Amino acid (building blocks of protein) and polyphenol supplements are commonly consumed post resistance exercise in order to aid muscle recovery. Both supplements have been shown to be beneficial in isolation, however, there is little known about the effect on recovery of combining the two.

Muscle recovery is related to the ability to build new muscle protein from amino acids (muscle protein synthesis). This response is thought to be impacted in females by hormones that fluctuate across different phases of the menstrual cycle. However, the effect of menstrual cycle phase on muscle protein synthesis during recovery is not known.

Condition Muscle Protein Synthesis
Treatment Bolus ingestion of protein, a blend of protein and polyphenol
Clinical Study IdentifierNCT05178732
SponsorUniversity of Exeter
Last Modified on20 June 2022


Yes No Not Sure

Inclusion Criteria

BMI between 18 and 30
Recreationally active
Regular menstrual cycle

Exclusion Criteria

Metabolic disease
Any motor disorder
Use of over-the-counter pharmaceuticals, during the study
Pomegranate, milk or lidocaine allergy
Taken contraceptives in the past 3 months
Irregular menstrual cycle (less than 9 cycles per year and a length not between 21-35 days)
Post-menopausal women
Pregnancy and lactation
Clear my responses

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