The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics

  • STATUS
    Recruiting
  • End date
    Feb 28, 2025
  • participants needed
    96
  • sponsor
    Philip Kern
Updated on 23 October 2022
insulin
body mass index
hemoglobin a1c
Accepts healthy volunteers

Summary

The investigator hypothesizes that treatment with the ß3 agonist mirabegron results in improved glucose metabolism, including a reversal of prediabetes in obese, insulin-resistant human research participants, and this is further improved by combination therapy with tadalafil. The investigator will comprehensively analyze glucose homeostasis in prediabetic patients treated for 14 weeks with mirabegron, tadalafil or both drugs as compared to a placebo.

Details
Condition Pre-diabetes, Obesity
Treatment Placebo, Mirabegron 50 MG, Tadalafil 10 MG
Clinical Study IdentifierNCT05051436
SponsorPhilip Kern
Last Modified on23 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Hemoglobin A1C between 5.7 and 6.4
Body mass index between 27 and 45

Exclusion Criteria

Diabetes
Chronic use of any antidiabetic medications
Any unstable medical condition
Use of steroids or daily use of NSAIDS
History of chronic inflammatory conditions
Use of anticoagulants
Contraindications to the use of mirabegron or tadalafil
Any condition deemed risky by the study physician
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