Epigenetic Regulation of Exercise Induced Asthma

  • STATUS
    Recruiting
  • End date
    Sep 26, 2022
  • participants needed
    68
  • sponsor
    Johann Wolfgang Goethe University Hospital
Updated on 26 March 2022
Accepts healthy volunteers

Summary

The purpose of this study is to investigate the micro ribonucleic acid (mRNA) profiles of patients with EIA without allergic sensitization and EIA with house dust mite sensitization compared to that of healthy controls.

Description

Patients with known EIA are periodically reexamined by medical history, clinical examination, bodyplethysmography, spirometry, exhaled nitric oxide (eNO), skin prick test, methacholin challenge test and exercise-challenge in a cold-chamber at 2-4°C (ECC). Additionally the investigators gathers the questionnaires: Asthma Control Test (ACT) and Dyspnoe Index (DI).

Besides these standard procedures the investigators want to investigate the micro-RNA profiles in two EIA subgroups: EIA with house-dust allergy (n = 24) and EIA without house-dust allergy (n = 24).

Both groups are characterized by different eNO levels. The patients with EIA and house-dust allergy should have an eNO > 30 ppb, the patients with EIA without house-dust allergy an eNO < 20 ppb.

The micro-RNA profiles of the both EIA subgroups will be compared the micro RNA profiles of 20 healthy controls .

Therefore blood will be taken (for a complete blood count and micro RNA analysis) at three points of time: before ECC, directly after ECC and after 24 hours ± 4 hours after ECC.

Details
Condition Exercise Induced Asthma, House Dust Mite Allergy
Treatment Exercise challenge in the cold chamber (ECC), mRNA profile, standard diagnostic
Clinical Study IdentifierNCT05174689
SponsorJohann Wolfgang Goethe University Hospital
Last Modified on26 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

written agreement
age >=18 and <= 24

Exclusion Criteria

age < 18 and > 24 years
known asthma bronchiale or other chronic lung diseases
lung function FVC < 90% and FEV1 < 80%
allergic sensitization in skin prick test
eNO > 30 ppb
inability to understand the range of the study
acute severe infection (pneumonia) within the last 4 weeks
other chronic diseases or infections (HIV, Tbc)
pregnancy
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