Low-Load Blood Flow Restriction on Patients With Multiple Sclerosis

  • End date
    Dec 31, 2022
  • participants needed
  • sponsor
    University of Central Florida
Updated on 25 March 2022


This research is being done to compare the current standard of care for strength training for patients with Multiple Sclerosis to lightweight resistance training with blood flow restriction.


The purpose of this study is to compare the effectiveness of the current Multiple Sclerosis standard of care exercise recommendations to low-load resistance training with blood flow restriction on functional outcomes, strength, muscle size, and neuromuscular control in Multiple Sclerosis patients. This study involves completing 2 training sessions per week for 12 weeks as well as pre- and post-training assessment visits for a total of 29 visits over 14 weeks. All visits will be on UCF's campus with a member of the research team.

Condition Training Study, Multiple Sclerosis, Blood Flow Restriction
Treatment Standard of Care, Blood Flow Restriction
Clinical Study IdentifierNCT05177952
SponsorUniversity of Central Florida
Last Modified on25 March 2022


Yes No Not Sure

Inclusion Criteria

Females between the ages of 18 to 55
Diagnosed with Multiple Sclerosis
Expanded Disability Status Score of 0 to 6.5
Able to walk 10 meters without assistance
Are willing to come in for all 29 testing visits over 14 weeks

Exclusion Criteria

No other known cardiovascular, pulmonary, metabolic, muscular, and/or coronary heart disease
Multiple Sclerosis relapse in the past 30 days
Are not currently undergoing a rehabilitation protocol
Are not currently seeking medical care for a chronic condition that could limit exercise capacity other than multiple sclerosis
Are not currently pregnant
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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