Non-invasive Placental Chromosome Exploration of Intrauterine Growth Restriction (DPNI-RCIU)

  • STATUS
    Recruiting
  • End date
    Oct 5, 2023
  • participants needed
    200
  • sponsor
    University Hospital, Bordeaux
Updated on 26 March 2022

Summary

The objective of this project is the non-invasive prenatal detection of placenta-limited aneuploidies, in patients whose fetuses have a intrauterine growth restriction below 3rd percentile, in parallel with an amniocentesis.

This study will allow the chromosomal study of the placenta in pregnant women whose genetic prenatal diagnosis, made by amniocentesis, does not allow exploring the placental causes of fetal RCIU.

Description

Placental chromosomal aneuploidies will be detected by high-throughput whole genome sequencing of non-cellular DNA present in maternal plasma during pregnancy.

The study of the cfDNA will be carried out from a blood sample with the automated solution VERISEQ NIPT (Illumina) using the software illumina VeriSeq v2, allowing the detection of all chromosomal abnormalities.

Details
Condition Fetal Growth Retardation
Treatment blood samples
Clinical Study IdentifierNCT05023161
SponsorUniversity Hospital, Bordeaux
Last Modified on26 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

over 18 years old
treated in the DDIANE fetal medicine centre at the Bordeaux University Hospital
having a fetus with IUGR diagnosis below the 3rd percentile (after reference medical ultrasound)
from 16 weeks of amenorrhea or more
accepting an Invasive Prenatal Diagnosis by amniocentesis with array comparative genomic hybridization

Exclusion Criteria

Childbearing women who
do not accept a non-invasive prenatal diagnosis (amniocentesis)
have a fetus with non-isolated IUGR (associated with other ultrasound signs)
do not consent to participate in the research protocol
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