Dual Antiplatelet Therapy Adherence With Reminder App Usage

  • STATUS
    Recruiting
  • End date
    Sep 25, 2024
  • participants needed
    68
  • sponsor
    Montefiore Medical Center
Updated on 25 March 2022

Summary

The purpose of this study is to evaluate Dual Antiplatelet Therapy adherence in patients undergoing stent-based endovascular treatment for unruptured cervical and intradural, intracranial aneurysms. Patients will be randomized on a 1:1 basis to either a medication reminder app group or a control group, with patients in both groups receiving the standard of care. The app in question, Endovascular Neurosurgery, is available on the app store. The app does not collect user data and has not been officially deemed HIPAA compliant. The only data inputted into the app are the patient's procedure date and the antiplatelet medications the patient has been prescribed. The app does not possess sensitive patient data. Patients will input the time notifications will be sent and the app will be available in both Spanish and English. The investigators will be assessing medication adherence via the Adherence Barriers Questionnaire.

Description

This will be a randomized control trial, with patients undergoing stent-based endovascular treatment for unruptured cervical and intradural, intracranial aneurysms. Informed consent will be obtained from participating patients. Patients will be assigned to either the app group or the control group.

The particular stent-based therapy, either flow-diverter devices [FDD] placement or stent-assisted coiling, will be chosen for each patient by the clinical team. During the study consultation, the app group will have the app installed on their smart phones and will be trained in its usage. Thromboelastography [TEG] and Aspirin inhibition percentage will be determined for each patient following the procedure. Patients with TEG less than 60% will have Dual Antiplatelet Therapy [DAPT] changed from 81 mg aspirin and 75 mg clopidogrel to 81 mg aspirin and 10 mg prasugrel. Patients with aspirin inhibition percentages of less than 20% will have their aspirin doses increased to 325 mg. Medication compliance of all participants will be assessed on the day of the procedure via a medication compliance questionnaire. The same questionnaire will be administered during follow-up appointments 2-4 weeks and 6 months post-procedure.

Details
Condition Aneurysm Cerebral (Unruptured)
Treatment Endovascular Neurosurgery
Clinical Study IdentifierNCT05071027
SponsorMontefiore Medical Center
Last Modified on25 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

years of age or older
Must speak either English or Spanish fluently
Physically able to come to the research site location
Elective stent-based procedures for unruptured cervical, and intracranial, intradural aneurysms
Endovascular therapy must be deemed appropriate by clinical team

Exclusion Criteria

Presence of aneurysm where treatment plan does not include dual anti-platelet therapy
Presence of comorbidities that preclude the possibility of treatment
Presence of contraindications to Dual Antiplatelet Therapy
Presence of certain vessel anatomical characteristics
Lack of iphone
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