Hypofractionated Radiotherapy for the Treatment of Cervical or Endometrial Cancer
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- STATUS
- Recruiting
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- End date
- Nov 15, 2025
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- participants needed
- 64
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- sponsor
- University of Utah
Summary
This clinical trial studies the feasibility of using hypo-fractionated radiotherapy for the treatment of cervical or endometrial cancer. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells and have fewer side effects.
Description
PRIMARY OBJECTIVE:
I. To establish the trial as feasible and to assess the impact upon acute gastrointestinal toxicity in the third week of pelvic radiotherapy following a hypo-fractionated schedule.
SECODARY OBJECTIVES:
I. To estimate impact upon acute urinary toxicity. II. To estimate impact upon patient reported gastrointestional toxicity. III. To assess acute quality of life following treatment. IV. To quantify acute financial toxicity following treatment. V. To assess satisfaction with decision-making following treatment. VI. To assess the overall survival throughout 3 years of post-treatment follow-up.
- OUTLINE
Patients undergo hypo-fractionated radiotherapy over 3 weeks in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up at 1, 3, and 6 months and then at 1, 2, and 3 years.
Details
| Condition | Cervical Carcinoma, Endometrial Carcinoma |
|---|---|
| Treatment | hypofractionated radiation therapy |
| Clinical Study Identifier | NCT05139368 |
| Sponsor | University of Utah |
| Last Modified on | 7 January 2022 |
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.
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