Phase I Study of N-Acetylcysteine to Optimize Metabolic Tumor Microenvironment in CD19 CAR T-cell Therapy in Lymphoma

  • End date
    Oct 21, 2024
  • participants needed
  • sponsor
    Memorial Sloan Kettering Cancer Center
Updated on 14 September 2022


The purpose of this study is to test the safety of N-AC when given in combination with Yescarta to people with lymphoma. This study will test different doses of N-AC to find the highest dose that causes few or mild side effects in participants.

Condition Lymphoma
Treatment N-acetylcysteine
Clinical Study IdentifierNCT05081479
SponsorMemorial Sloan Kettering Cancer Center
Last Modified on14 September 2022


Yes No Not Sure

Inclusion Criteria

Patients must be 18 years of age or older
Patients who will receive axicabtagene ciloleucel for treatment of lymphoma
Patients must have adequate end organ function to be eligible for this study as defined by the following criteria
ECOG performance status 0-2
Hematologic function with ANC ≥ 1000, Hgb ≥ 8, Plt ≥ 50k unless there is disease related hematologic toxicity
Renal function with CrCr ≥ 40 ml/min or Cr ≤ 1.5 x ULN
Hepatic function with ALT/AST ≤ 2.5 x ULN, TBili ≤ 1.5 x ULN

Exclusion Criteria

Patients with known allergy to N-AC
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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