Spinal Cord Stimulation for Multiple System Atrophy

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  • participants needed
  • sponsor
    Ruijin Hospital
Updated on 23 March 2022
orthostatic hypotension


Spinal Cord Stimulation (SCS) is a newly emerged neuromodulation technique in recent years. It is now a mature technique in the treatment of chronic pain and is generally accepted by patients because of its non-destructive and reversible nature, few complications, no side effects, and avoidance of unnecessary surgical procedures. Combining the results of previous studies and the group's previous research, this study first proposes an innovative treatment protocol for multiple system atrophy with SCS in C2-4 segment. We intend to conduct a prospective single-center open clinical trial to evaluate the improvement of dysarthria, dysphagia, urinary retention and orthostatic hypotension in multiple system atrophy (MSA) patients before and after SCS treatment, and shed new light on the treatment for MSA.

Condition Multiple System Atrophy
Treatment Spinal cord stimulation
Clinical Study IdentifierNCT05171205
SponsorRuijin Hospital
Last Modified on23 March 2022


Yes No Not Sure

Inclusion Criteria

Meeting possible or probable multiple system atrophy (MSA) criteria according to the 2008 second consensus statement on the diagnosis of MSA
Citizens of the People's Republic of China, aged >18 years and <80 years
Hoehn-Yahr stage ≤3
The presence of significant symptoms of dysarthria, dysphagia, orthostatic hypotension or urinary hypotension in patients with MSA
Maintaining medication during the study period
Good compliance, signed written informed consent, and consent to surgical treatment of cervical spinal cord stimulation (SCS)

Exclusion Criteria

Patients with severe neuropsychiatric disorders or a history of severe neuropsychiatric disorders
Patients with significant cognitive impairment (Mini-Mental State Exam < 24) or inability to complete the questionnaire independently
Presence of anatomical abnormalities or other lesions of the cervical spine that interfere with electrode implantation
Dysarthria, swallowing difficulties, orthostatic hypotension from other causes not related to MSA
Critically ill or unstable vital signs
Other conditions that in the opinion of the investigator make them unsuitable for participation in this study
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