Spinal Cord Stimulation for Multiple System Atrophy

  • STATUS
    Recruiting
  • days left to enroll
    83
  • participants needed
    33
  • sponsor
    Ruijin Hospital
Updated on 23 March 2022
orthostatic hypotension

Summary

Spinal Cord Stimulation (SCS) is a newly emerged neuromodulation technique in recent years. It is now a mature technique in the treatment of chronic pain and is generally accepted by patients because of its non-destructive and reversible nature, few complications, no side effects, and avoidance of unnecessary surgical procedures. Combining the results of previous studies and the group's previous research, this study first proposes an innovative treatment protocol for multiple system atrophy with SCS in C2-4 segment. We intend to conduct a prospective single-center open clinical trial to evaluate the improvement of dysarthria, dysphagia, urinary retention and orthostatic hypotension in multiple system atrophy (MSA) patients before and after SCS treatment, and shed new light on the treatment for MSA.

Details
Condition Multiple System Atrophy
Treatment Spinal cord stimulation
Clinical Study IdentifierNCT05171205
SponsorRuijin Hospital
Last Modified on23 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Meeting possible or probable multiple system atrophy (MSA) criteria according to the 2008 second consensus statement on the diagnosis of MSA
Citizens of the People's Republic of China, aged >18 years and <80 years
Hoehn-Yahr stage ≤3
The presence of significant symptoms of dysarthria, dysphagia, orthostatic hypotension or urinary hypotension in patients with MSA
Maintaining medication during the study period
Good compliance, signed written informed consent, and consent to surgical treatment of cervical spinal cord stimulation (SCS)

Exclusion Criteria

Patients with severe neuropsychiatric disorders or a history of severe neuropsychiatric disorders
Patients with significant cognitive impairment (Mini-Mental State Exam < 24) or inability to complete the questionnaire independently
Presence of anatomical abnormalities or other lesions of the cervical spine that interfere with electrode implantation
Dysarthria, swallowing difficulties, orthostatic hypotension from other causes not related to MSA
Critically ill or unstable vital signs
Other conditions that in the opinion of the investigator make them unsuitable for participation in this study
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact

site

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Loading...

Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 

 • 

Private

Reply by • Private
Loading...

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.
Loading...

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note