Long Term Follow up of Chronic HCV Patients Receiving DAAS

  • days left to enroll
  • participants needed
  • sponsor
    Sohag University
Updated on 7 July 2022


Follow up of Chronic hepatitis C Patients with moderate to severe fibrosis and cirrhosis treated with Direct Acting Antivirals after Sustained Virological Response for 4-5 years to detect changes in hepatic fibrosis and liver functions.


Treatment of chronic hepatitis C is evolving rapidly. Three classes of direct-acting antiviral agents, including inhibitors of the HCV NS3/4A protease, NS5B polymerase, and NS5A have been approved for the treatment of patients with chronic hepatitis C, both in combination with pegylated Interferon (Peg-IFN) / ribavirin (RBV) and, recently, in interferon-free combination.

The objective of chronic hepatitis C treatment is to achieve SVR which is defined as the absence of viral replication at 12 or 24 weeks after treatment completion. SVR reduces morbidity and mortality and is equivalent in most cases to cure the HCV infection. Studies have demonstrated that SVR is associated with histological improvement, assessed by liver biopsy, and with the prevention of complications, such as the development of liver cirrhosis and HCC.

Condition Chronic Hepatitis c
Clinical Study IdentifierNCT05170490
SponsorSohag University
Last Modified on7 July 2022


Yes No Not Sure

Inclusion Criteria

Chronic HCV patients with moderate to severe hepatic fibrosis (F2: F4) or cirrhosis who received direct-acting antivirals and achieved SVR

Exclusion Criteria

Other liver diseases as Chronic hepatitis B and autoimmune liver disease. HIV co-infection
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