Individualized Closed Loop TMS for Working Memory Enhancement

  • End date
    Jan 27, 2025
  • participants needed
  • sponsor
    University of Pennsylvania
Updated on 27 December 2021
Accepts healthy volunteers


The study is investigating working memory brain states by using transcranial magnetic stimulation (TMS) in combination with functional magnetic resonance imaging (fMRI). The study uses a novel, individualized targeting approach for TMS based on each subject's individual multi-modal fMRI data. Next, the individualized target will be stimulated in a TMS/ fMRI imaging session to investigate working memory states and optimal stimulation frequencies.

Condition Working Memory in Healthy Participants
Treatment Repetitive Transcranial Magnetic Stimulation (rTMS)
Clinical Study IdentifierNCT04402294
SponsorUniversity of Pennsylvania
Last Modified on27 December 2021


Yes No Not Sure

Inclusion Criteria

-60 years old
Right handed
No current or lifetime history of any DSM-V diagnosis
No history of neurological disorder or traumatic brain injury (other than mild)
No current psychoactive medication use
Normal cognition
Female patients must attest to not being pregnant
Capacity to give informed consent and follow study procedures
Sufficient command of English language to understand and respond to written as well as verbal instructions

Exclusion Criteria

Unable to have an MRI scan, including current or prior medical condition that could interfere with the collection or interpretation of MRI data
Implanted devices, such as an aneurysm clip or cardiac pacemaker
History of stroke, epilepsy, or brain scarring
Cognitive impairment
Recent use of psychoactive medications, as determined by investigators
People who are unwilling/unable to abstain from medications that substantially reduce the seizure threshold to TMS under PI discretion
Otherwise determined by investigator to be unfit for study
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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