JMT101 Combined With Afatinib in Patients With Advanced Esophageal Squamous Cell Carcinoma After Standard Therapy

  • STATUS
    Recruiting
  • End date
    Oct 25, 2023
  • participants needed
    50
  • sponsor
    Peking University
Updated on 26 December 2021

Summary

This study is a multi-center, open-label, phase Ib study to evaluate the safety, tolerability and efficacy of JMT101 combined with afatinib in patients with advanced esophageal squamous cell carcinoma who have failed standard treatment.

Description

This is a multicenter, open-label, dose-escalated phase Ib study aimed to evaluate the safety, tolerability, and efficacy of JMT101 combined with afatinib in patients with advanced esophageal squamous cell carcinoma who have failed standard treatment. This study consists of two stages: dose-escalation stage and dose expansion stage. The dose-escalation stage will be conducted to determine the maximum tolerated dose (MTD) of JMT101 combined with afatinib in patients with advanced esophageal squamous cell carcinoma based on a 3+3 design. JMT101 will be given by intravenous infusion at 6 mg/kg (q2w) of each 28-week cycle. Afatinib will be sequentially administered at 30 mg and 40 mg (qd) of each 28-week cycle. One dose cohort which is verified to be well-tolerated and safe in dose-escalation stage will be selected for dose-expansion to further explore the safety, pharmacokinetic and efficacy of the study drug.

Details
Condition Esophageal Squamous Carcinoma
Treatment Afatinib, JMT101
Clinical Study IdentifierNCT05164848
SponsorPeking University
Last Modified on26 December 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Age of 18 years or above, without gender limitation
Histological or cytologically confirmed esophageal squamous cell carcinoma
Patients with metastatic disease or locally advanced disease (UICC or AJCC 8th Edition) unsuitable for radical surgery or radiotherapy; with direct invasion of adjacent organs (such as aorta or trachea) (T4b) should be closely assessed for the risk of bleeding before enrollment
Patients who have failed first-line or above treatments. The treatment failure is defined as disease progression or intolerable toxicity during or after the last dose of systemic standard chemotherapy, and recurrence or metastasis during treatment or within 6 months of discontinuation of radical therapy including radical concurrent chemoradiotherapy and neoadjuvant/adjuvant therapy (chemotherapy or chemoradiotherapy)
At least 1 measurable lesion according to RECIST 1.1 at baseline; if there is only one measurable lesion at baseline, the area must have not had prior radiotherapy or there must be evidence of apparent progression after radiotherapy
Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2
Life expectancy exceeds 3 months
The function of major organs and bone marrow meet the following criteria within 7 days before treatment (No blood transfusion, erythropoietin (EPO), granulocyte colony stimulating factor (G-CSF), granulocyte-macrophage colony stimulating factor (GM-CSF), or other support therapy within 7 days prior to administration of the study drug)
Blood routine: absolute neutrophil count (ANC) ≥1.5×10^9/L, platelet count
≥80×10^9/L, hemoglobin ≥80 g/L; Kidney function test: Serum creatinine
≤1.5×upper limit of normal (ULN); Liver function tests: total bilirubin
≤1.5×ULN (≤3×ULN for patients with liver metastasis), aspartate
aminotransferase ( AST) and alanine aminotransferase (ALT ) ≤3×ULN ( ≤5×ULN
for patients with liver metastasis); Blood coagulation: International
normalized ratio (INR) or prothrombin time (PT) ≤1.5×ULN, activated partial
thromboplastin time (APTT) ≤ 1.5×ULN
The fertile women should have a negative blood pregnancy test within 7 days before enrollment; fertile men or women must agree to use effective contraceptive methods during the whole trial period and six months after the last administration
Patients fully understand and voluntarily participate in this study and sign informed consent

Exclusion Criteria

Previously treated with EGFR antibody
Patients whose tumor has invaded important blood vessels or is much more likely to invade important blood vessels and cause fatal hemorrhage during the study according to the investigator's judgement; patients who have hemorrhage in the lung or other parts, have a bleeding tendency, or are receiving thrombolytic or anticoagulant therapy
Anti-tumor therapy such as chemotherapy, biological therapy, targeted therapy, immunotherapy, etc. within 4 weeks before the first administration of the study drug; oral small molecule targeting drugs within 2 weeks of the first dose or within the 5 half-life of known drugs (whichever is longer); radiotherapy within 2 weeks before the first administration of the study drug
Received other investigational product within 4 weeks before the first administration of the study drug
Received major organ surgery (excluding needle biopsy) or suffered significant trauma within 4 weeks before the first administration of the study drug
Received strong inducers and strong inhibitors of P-gp within 2 weeks before the first administration of the study drug
Uncontrolled cancer pain; not at a stable dose of anesthetic analgesics at the time of enrollment
Adverse reactions of previous anti-tumor treatments have not yet recovered to ≤ grade 1 according to CTCAE 5.0 (except for the toxicity without safety risk judged by investigator, such as alopecia)
Central nervous system metastasis or meningeal metastasis
History of autoimmune disease or immunodeficiency disease including human immunodeficiency virus antibody (HIV-Ab) positive, or suffering from other acquired or congenital immunodeficiency diseases, or history of organ transplantation
Active hepatitis B, active hepatitis C, or positive for treponema pallidum antibodies
History of severe cardiovascular disease
History of other malignancies within 5 years before the first administration of the study drug, except: malignant lesions that have been treated with therapeutic measures and no known active lesions within 5 or more years before enrolment, and are judged by the treating physician to be at low risk of recurrence; adequately treated non-melanoma skin cancer and cervical cancer in situ without evidence of progression; or prostatic intraepithelial neoplasia without evidence of recurrence of prostate cancer
Patients with any severe or uncontrollable disease are unsuitable to participate in this clinical trial according to the investigator's judgement
Known hypersensitivity or intolerance to any component of the study drug or its excipients
Past or present interstitial pneumonia/pulmonary disease
Pregnant or lactating women
Other situations that may increase the risks related to the study drug or affect compliance of the trial compliance are not suitable for the trial as determined by the investigator
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