Aspiration in Acute Respiratory Failure Survivors 2

  • End date
    Dec 15, 2025
  • participants needed
  • sponsor
    University of Colorado, Denver
Updated on 31 December 2021


The purpose of this study is to learn more about problems with swallowing that could develop in patients who are very sick and need a machine to help them breathe.


The purpose of this study is to learn more about problems with swallowing that could develop in patients who are very sick and need a machine to help them breathe. Patients are asked to be in this study because they had problems breathing on their own and therefore needed the help of a machine called a ventilator. In order for this ventilator to push air into the lungs, patients need a tube placed in the throat called an endotracheal tube. The process of placing this endotracheal tube was called intubation. The tube has now been removed, which is a process called extubation. Sometimes, people who have had endotracheal tubes can have difficulty swallowing food and liquids for a period of time. This disease is called post-extubation dysphagia (PED). PED is a serious condition and may result in food or liquid going from the mouth into the lungs. This could cause further lung problems. Given this risk, doctors sometimes suggest that patients with PED either avoid eating or drinking, or get a feeding tube. Currently, nobody knows how often patients develop PED, why they develop it, or the best method to detect it. Standard care involves clinicians making educated guesses. This study looks to determine if watching the patient swallow, both with and without a small camera, is an accurate method for detecting PED.

Condition Dysphagia, Aspiration
Treatment FEES, tracheal ultrasound, 3-Screenings Protocol
Clinical Study IdentifierNCT05108896
SponsorUniversity of Colorado, Denver
Last Modified on31 December 2021


Yes No Not Sure

Inclusion Criteria

Admission to an ICU
Mechanical ventilation with an endotracheal tube for greater than 48 hours

Exclusion Criteria

Contraindication to enteral nutrition administration
Pre-existing history of dysphagia or aspiration
Pre-existing or acute primary central or peripheral neuromuscular disorder
Presence of a chronic tracheostomy (present prior to ICU admission)
Pre-existing head and neck cancer or surgery
Coagulopathy resulting in uncontrolled nasal or pharyngeal bleeding
Delirium for more than 72 hours after extubation as assessed by Confusion Assessment Method (CAM-ICU)
Extubated for greater than 72 hours
Inability to obtain informed consent from patient or an appropriate surrogate
Age < 18 years
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