Extraction and Socket Preservation Before Implant Placement Using Freezed Dried Allograft (FDBA) and Platelet-Rich Fibrin in Smokers
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- STATUS
- Recruiting
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- End date
- Mar 20, 2023
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- participants needed
- 40
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- sponsor
- King Saud University
Summary
the investigators aim from this study to evaluate platelet rich fibrin potential to heal the periodontal tissue and to form new native bone in smokers that require socket augmentation following dental extraction and before implant placement.
Materials and Methods: forty adult smoker patients well be recruited for this study, and the participants well be distributed to four different groups as follow; Group 1- PRF alone, Group 2- Factors-enriched bone graft matrix (commonly known as steaky bone) using autologous fibrin glue combined with an FDBA with CGF-Enriched Fibrin Membrane to covered it, Group 3- an FDBA with a resorbable collagen membrane and Group 4-Resorbable collagen plug (RCP) alone serving as a negative control group.
The patients well be randomly grouped to a previously mentioned group, and the socket dimensions well be measured four times, immediately after the extraction (0 days), after 10, 21 and 28 days to assess epithelial layer healing. After six months and before placing the fixture, both soft and hard tissue samples well be harvested to be evaluated and compared histologically, also standardized CBCT will be taken before and after extraction to evaluate the amount of mineral content and vital bone formation radiographically.
Details
| Condition | L-PRF |
|---|---|
| Treatment | Platelet rich fibrin |
| Clinical Study Identifier | NCT05161455 |
| Sponsor | King Saud University |
| Last Modified on | 22 December 2021 |
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