Extraction and Socket Preservation Before Implant Placement Using Freezed Dried Allograft (FDBA) and Platelet-Rich Fibrin in Smokers

  • STATUS
    Recruiting
  • End date
    Mar 20, 2023
  • participants needed
    40
  • sponsor
    King Saud University
Updated on 22 December 2021
Accepts healthy volunteers

Summary

the investigators aim from this study to evaluate platelet rich fibrin potential to heal the periodontal tissue and to form new native bone in smokers that require socket augmentation following dental extraction and before implant placement.

Materials and Methods: forty adult smoker patients well be recruited for this study, and the participants well be distributed to four different groups as follow; Group 1- PRF alone, Group 2- Factors-enriched bone graft matrix (commonly known as steaky bone) using autologous fibrin glue combined with an FDBA with CGF-Enriched Fibrin Membrane to covered it, Group 3- an FDBA with a resorbable collagen membrane and Group 4-Resorbable collagen plug (RCP) alone serving as a negative control group.

The patients well be randomly grouped to a previously mentioned group, and the socket dimensions well be measured four times, immediately after the extraction (0 days), after 10, 21 and 28 days to assess epithelial layer healing. After six months and before placing the fixture, both soft and hard tissue samples well be harvested to be evaluated and compared histologically, also standardized CBCT will be taken before and after extraction to evaluate the amount of mineral content and vital bone formation radiographically.

Details
Condition L-PRF
Treatment Platelet rich fibrin
Clinical Study IdentifierNCT05161455
SponsorKing Saud University
Last Modified on22 December 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Current smokers
have at least one tooth indicated for extraction due to extensive decay, tooth fracture or failed root canal treatment
years of age or older
give a written consent to participate in the trial
have the desire to have an implant restoration for at least one non-restorable tooth
indicated for socket preservation procedures and generally healthy with no systematic disease

Exclusion Criteria

subjects who unable to undergo oral surgery procedures due to a medical
condition
women who are pregnant or nursing a child
subjects with dental infection of bone, active periodontal disease and ankylosed teeth
Subjects with following systemic diseases and conditions: Chemotherapy or radiation for the treatment of cancer and arthritis, seriously impaired cardiovascular or pulmonary function, uncontrolled diabetes, auto-immune compromised diseases, kidney or liver disease and history of severe, multiple allergies
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