Safety and Efficacy of THR-1442 Compared to Dapagliflozin as Add-on Therapy to Metformin in T2DM

  • participants needed
  • sponsor
    Newsoara Biopharma Co., Ltd.
Updated on 3 October 2022


The purpose of this study is to investigate the effect of THR-1442 compared to Dapagliflozin as an add-on therapy to metformin in lowering hemoglobin A1c (HbA1c) levels in subjects with type 2 diabetes mellitus (T2DM).


Approximately 390 subjects with inadequately controlled T2DM on metformin were to be recruited from China. Subjects were randomly assigned to receive THR-1442 tablet, 20 mg, or Dapagliflozin tavlet,10 mg, in a ratio of 1:1 once daily for 24 weeks. Subjects were to continue taking metformin for the duration of the study.

Condition T2DM
Treatment THR-1442 and Dapagliflozin placebo, Dapagliflozin 10mg and THR1442 placebo
Clinical Study IdentifierNCT05159882
SponsorNewsoara Biopharma Co., Ltd.
Last Modified on3 October 2022

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