Transcranial Alternating Current Stimulation (tACS) for Auditory Hallucinations

  • End date
    May 28, 2023
  • participants needed
  • sponsor
    Shanghai Mental Health Center
Updated on 24 December 2021
auditory hallucinations


Transcranial alternating current stimulation (tACS) can modulate and restore neural oscillations that are reduced in patients with psychiatric illnesses such as schizophrenia. Here, we performed a open-lable study of clinical trial in 30 schizophrenia patients with auditory hallucinations to show that tACS is effective for auditory hallucinations.


Each week, the patient rested quietly with her eyes open while receiving alpha-frequency tACS for 40 minutes. Stimulation was delivered at 10 Hz with 1 mA zero-to-peak amplitude in-phase to the location 1 and the location 2 acquired by the MEG technique with 55 cm electrodes. A 5 7 cm return electrode was centered on Cz. In total, 20 weeks.

Condition Schizophrenia
Treatment tACS for auditory hallucinations via single arm
Clinical Study IdentifierNCT05159336
SponsorShanghai Mental Health Center
Last Modified on24 December 2021


Yes No Not Sure

Inclusion Criteria

Schizophrenia with auditory hallucinations was diagnosed by DSM-IV, AHRS >12, Take sufficient antipsychotics for at least 1 month

Exclusion Criteria

current pregnancy, major medical illness affecting the central nervous system, significant neurologic disorders, intake of drugs including supplements like essential fatty acids that influence prostaglandins or niacin skin flush flash pathway metabolism, a history of suicide risk, or alcohol or drug abuse
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