Intravenous Esketamine on Prevention of Postoperative Depression in Patients Undergoing Cardiac Surgery

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    Anshi Wu
Updated on 22 December 2021


Esketamine is a general anesthetic with anti-depressant effects at subanaesthetic doses. This study hypothesized that intraoperative administration of ketamine would prevent or mitigate postoperative depressive symptoms in surgical patients.


Single subanaesthetic doses of i.v. esketamine may significantly improve symptoms in psychiatric patients with major depression.

In patients undergoing cardiac surgery, postoperative depressive symptoms are common.

This study hypothesizes that low-dose esketamine has a preventive effect on postoperative depression. However, evidence in this aspect is insufficient. The purpose of this study is to investigate the effect of a subanaesthetic dose of ketamine on POD for patients undergoing cardiac surgery.

Condition Postoperative Depression
Treatment Normal saline, Esketamine
Clinical Study IdentifierNCT05155969
SponsorAnshi Wu
Last Modified on22 December 2021


Yes No Not Sure

Inclusion Criteria

Patients scheduled for heart surgery
Moderate to severe depressive symptom measured by the qualified psychiatric doctors
Over 18 years of age
American Society of Anesthesiologists physical status I-III

Exclusion Criteria

History of epilepsy
Major depression disorder patients undergoing antidepressive therapy within 2 weeks
Psychiatric illness
Drug abuse
History of allergy to esketamine
Patients can not cooperate with investigators on psychiatric assessments
Pregnant or breastfeeding woman
refuse to sign informed consent
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