Study on the Establishment of a System for Early Warning and Prognostic Evaluation of Patients With Heat Stroke

  • End date
    Dec 24, 2023
  • participants needed
  • sponsor
    Xijing Hospital
Updated on 4 October 2022
Accepts healthy volunteers


Heat stroke is a clinical syndrome with high incidence and high fatality rate in summer. Patients with liver, kidney, and brain damage are prone to secondary MODS, and the prognosis is poor due to high medical costs. At present, there is no unified diagnostic criteria for acute liver injury associated with heat stroke, and the commonly used prognosis scores are rarely included in liver injury indicators, which is not good for practicality.


The project intends to collect the peripheral blood of the normal population, the 24 hours after the onset of heat stroke and the patients in the recovery period, to separate and extract plasma, PBMC, and plasma exosomal miRNA, and sequence to search for indicators related to disease deterioration and prognosis, construct and verify the early warning and prognosis evaluation system of the disease.

On this basis, the researcher explore cellular and molecular mediated pathological mechanisms of heat stroke, and then clarify the treatment target of heat stroke.

Condition Heat Stroke, Early Waking, MODS, Proteinosis, Liver Injury, Kidney Injury
Treatment Peripheral blood test
Clinical Study IdentifierNCT05155358
SponsorXijing Hospital
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

The patient voluntarily signs an informed consent form
Adult patients who meet the criteria for heat stroke
Heat stroke is defined as heat stroke (Heat Stroke, HS) is a serious fatal disease caused by heat injury factors acting on the body, accompanied by multiple organ damage

Exclusion Criteria

Age <18 years old or >90 years old
Patients with advanced tumors, Pregnancy or lactation
Patients who missed out during treatment and whose data are incomplete
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