Prospective Cohort Study of Changes in Circulatory MicroRNA of Resected Hepatocellular Carcinoma

  • STATUS
    Recruiting
  • End date
    Feb 21, 2025
  • participants needed
    100
  • sponsor
    National Cancer Centre, Singapore
Updated on 18 December 2021
cancer
TACE

Summary

Hepatocellular carcinoma (HCC) is the 4th most common cause of cancer death globally but only 20% are diagnosed in its early stages where curative treatment can be carried out. Current standard-of-care surveillance of patients at high risk of developing HCC with 6-monthly serum alpha-fetoprotein (AFP) and ultrasound imaging (US) has a sensitivity of approximately 63% for detecting early HCC. There is an urgent need for a more efficacious and convenient modality of surveillance of high-risk patients to diagnose HCC at an early stage. In another study (AHCC10 ELEGANCE, NCT04965259), 2,000 patients at risk of developing HCC will be enrolled to develop the 1st miRNA in-vitro diagnostic (IVD) kit for HCC that has higher accuracy and better ease of use compared with the extant combination of AFP and US.

This prospective study will act as a positive control to the AHCC10 ELEGANCE Study and aims to address the absence of efficacious modalities of surveillance by validating a panel of circulating miRNA biomarkers signatures with histologically proven HCC. This study will determine progressive changes in the profiles of miRNA signatures pre- and post- surgical resection to identify signatures predictive of recurrence.

Additionally, this study also aims to identify changes in key metabolites and microbiome with correlation to changes in choline, bile acid and tryptophan metabolic pathways in the gut microbiota to establish actionable biomarkers that can predict HCC recurrence.

Description

This is a prospective study involving 100 patients with diagnosis of hepatocellular carcinoma (HCC) confirmed by histology at surgical resection. Eligible patients will receive CT scans at 6 months and 12 months post-surgery to monitor for recurrence. Pre- and post-surgery bio-samples (blood, urine, stool) will also be collected to monitor changes in profiles of miRNA, metabolome and microbiome.

Details
Condition Hepatocellular Carcinoma
Clinical Study IdentifierNCT05148572
SponsorNational Cancer Centre, Singapore
Last Modified on18 December 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

The patient is male or female patients, 21 to 90 years of age at the time of signature of the informed consent form
The patient has clinically AND histologically proven HCC
The patient has R0 or R1 resection on histology
The patient has Child-Pugh <= 7 points without clinical ascites before surgery
The patient has ECOG performance status 0-1 before surgery
The patient is scheduled for liver resection within 6 weeks of signing screening informed consent form
The patient has received no anti-cancer specific treatment for HCC before the surgery (eg. previous liver resection, loco-regional therapy such as RFA, TACE, SIRT, radiotherapy, immunotherapy, chemotherapy or neo-adjuvant chemotherapy), other than the planned surgery. However, patient who has received previous HCC resection more than 5 years ago is deemed to have a de-novo liver tumour and therefore can be included
The patient is able to comply with scheduled visits, assessments and other study procedures
The patient is willing to provide informed consent before enrolment in the study

Exclusion Criteria

The patient has previous or concomitant malignancies at other sites, except effectively treated non-melanoma skin cancers or carcinoma in situ of the cervix or effectively treated malignancy that has been in remission for over 5 years and highly likely to have been cured
The patient has active hepatic encephalopathy at time of enrolment
The patient has received a major organ allograft
The patient is known to be positive for the Human Immunodeficiency Virus (HIV)
The patient has an uncontrolled bleeding disorder
The patient has uncontrolled congestive heart failure or hypertension, unstable heart disease (coronary artery disease or myocardial infarction) or uncontrolled arrhythmia at the time of enrolment
The patient has psychiatric or addictive disorders that may compromise his/her ability to give informed consent, or to comply with the study procedures
The patient has other concurrent severe medical problems, unrelated to the malignancy, that would significantly limit full compliance with the study or expose the patient to unacceptable risk
The patient has received any investigational or non-registered medicinal product (drug or vaccine) within the 30 days preceding the date of enrolment, or plans to receive such a drug during the study period
For female patients: the patient is pregnant or lactating
The patient is unable to provide informed consent or refuse blood taking
The patient has any other condition which, in the opinion of the Investigators, would make the patient unsuitable for enrolment or could interfere with completion of the study
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