Radiotherapy and Anti-PD-1 in Low-risk ES-ENKTCL

  • STATUS
    Recruiting
  • End date
    Sep 30, 2024
  • participants needed
    30
  • sponsor
    Chinese Academy of Medical Sciences
Updated on 19 December 2021

Summary

The current study is a phase II multi-center single arm trial to evaluate the efficacy and safety of adding Anti-PD-1 antibody in an inductive and concurrent way to radiotherapy in early-stage low-risk extranodal NK/T cell lymphoma, nasal type

Details
Condition Early-stage, Extranodal NK-T-Cell Lymphoma, Nasal and Nasal-Type
Treatment Anti-PD-1 monoclonal antibody
Clinical Study IdentifierNCT05149170
SponsorChinese Academy of Medical Sciences
Last Modified on19 December 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Biopsy proved extranodal NK/T cell lymphoma
No previous anti-cancer treatment
Measurable lesion on baseline PET/CT and MRI
Stage I
Normal serum LDH level
Primary tumor invasion (PTI) absence
ECOG PS 0-1
Sufficient organ functions

Exclusion Criteria

Other mature T- or NK- lymphoma
Hemophagocytic lymphohistiocytosis
Primary CNS lymphoma or CNS-involved lymphoma
History of malignancy except for cutaneous basal-/squamous- cell carcinoma or cervical carcinoma in situ 3 years prior to study treatment
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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