Radiotherapy and Anti-PD-1 in Low-risk ES-ENKTCL

  • End date
    Sep 30, 2024
  • participants needed
  • sponsor
    Chinese Academy of Medical Sciences
Updated on 19 December 2021


The current study is a phase II multi-center single arm trial to evaluate the efficacy and safety of adding Anti-PD-1 antibody in an inductive and concurrent way to radiotherapy in early-stage low-risk extranodal NK/T cell lymphoma, nasal type

Condition Early-stage, Extranodal NK-T-Cell Lymphoma, Nasal and Nasal-Type
Treatment Anti-PD-1 monoclonal antibody
Clinical Study IdentifierNCT05149170
SponsorChinese Academy of Medical Sciences
Last Modified on19 December 2021


Yes No Not Sure

Inclusion Criteria

Biopsy proved extranodal NK/T cell lymphoma
No previous anti-cancer treatment
Measurable lesion on baseline PET/CT and MRI
Stage I
Normal serum LDH level
Primary tumor invasion (PTI) absence
Sufficient organ functions

Exclusion Criteria

Other mature T- or NK- lymphoma
Hemophagocytic lymphohistiocytosis
Primary CNS lymphoma or CNS-involved lymphoma
History of malignancy except for cutaneous basal-/squamous- cell carcinoma or cervical carcinoma in situ 3 years prior to study treatment
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