Prophylactic Norepinephrine Infusion Combined With Colloid Coloading for Postspinal Anesthesia Hypotension

  • STATUS
    Not Recruiting
  • participants needed
    150
  • sponsor
    General Hospital of Ningxia Medical University
Updated on 5 December 2022

Summary

The purpose of this study is to investigate the suitable infusion dose of prophylactic norepinephrine infusion combined with 6% Hydroxyethyl starch (130/0.4) coload for post-spinal anesthesia hypotension in patients undergoing cesarean section.

Description

Post-spinal anesthesia hypotension is a frequent complication during spinal anesthesia for cesarean section. The incidence of post-spinal anesthesia hypotension is as high as 62.1-89.7% if prophylactic measures are not taken. Vasopressor has been highly recommended for routine prevention and/or treatment of post-spinal anesthesia hypotension. As a potential substitute drug for phenylephrine, norepinephrine has gradually been used in parturients undergoing cesarean section. There's some evidence that prophylactic infusion of norepinephrine could effectively reduce the incidence of post-spinal anesthesia hypotension in parturients undergoing cesarean section. But the ideal infusion dose of norepinephrine with colloid coload is still unknown. The purpose of this study is to investigate the suitable infusion dose of prophylactic norepinephrine infusion combined with 6% Hydroxyethyl starch (130/0.4) coload for post-spinal anesthesia hypotension in patients undergoing cesarean section.

Details
Condition Adverse Event
Treatment Normal saline, Norepinephrine (0.025 μg/kg/min), Norepinephrine (0.05 μg/kg/min), Norepinephrine (0.075 μg/kg/min), Norepinephrine (0.1 μg/kg/min)
Clinical Study IdentifierNCT05133817
SponsorGeneral Hospital of Ningxia Medical University
Last Modified on5 December 2022

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