Impact of Tamsulosin on Post-Operative Urinary Retention Following Pelvic Reconstructive Surgery

  • End date
    May 16, 2023
  • participants needed
  • sponsor
    Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Updated on 16 December 2021
Accepts healthy volunteers


The objective of the study is to determine the effectiveness of postoperative Tamsulosin in reducing the duration of acute postoperative urinary retention (POUR) following pelvic reconstructive surgery through a double blind, randomized placebo-controlled trial.


The primary objective is to determine the impact of Tamsulosin on duration of urinary retention following pelvic reconstructive surgery in women. Duration of catheterization via indwelling foley or clean intermittent self-catheterization (CISC), measured in days, will be compared between women receiving Tamsulosin versus placebo after diagnosis of postoperative urinary retention via standardized voiding trial. It is hypothesized that women receiving Tamsulosin will have a shorter duration of urinary retention, fewer urinary tract infections, and improved quality of life as compared with placebo. The Euroqol-5D (EQ-5D) will be used to compare physical, emotional, functional, and social/family well-being between women receiving Tamsulosin and placebo.

Upon diagnosis of POUR, women will be offered participation in the study. Once consent is obtained, women will be randomized to tamsulosin 0.4 mg or matching placebo capsules to be used daily until resolution of POUR or a 10 day course, whichever occurs first.

Condition Urinary Retention Postoperative
Treatment Placebo, Tamsulosin
Clinical Study IdentifierNCT04597372
SponsorAllegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Last Modified on16 December 2021


Yes No Not Sure

Inclusion Criteria

years or older
willing and able to provide informed consent
postoperative urinary retention as defined by a failed RGVT prior to hospital discharge
Ability to speak and read English
Tolerate pill ingestion

Exclusion Criteria

allergy/intolerance to Tamsulosin or sulfa drugs
preoperative history of urinary retention as defined by preoperative post void residual of >150mL
current use of alpha antagonist medication for hypertension
severe dementia
end stage renal or liver disease
history of severe heart failure or major cardiovascular event in the last 6 months
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note