Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome (IRM SAOS)

  • STATUS
    Recruiting
  • End date
    Feb 26, 2023
  • participants needed
    70
  • sponsor
    CHU de Reims
Updated on 26 May 2022
collapse
sleep disorder
somnolence
obstructive sleep apnea
apnea-hypopnea index
Accepts healthy volunteers

Summary

The obstructive sleep apnea syndrome (OSAS) involves recurrent sleep-related upper airways (UA) collapse. UA mechanical properties and neural control are altered, imposing a mechanical load on inspiration. UA collapse does not occur during wakefulness, hence arousal-dependent compensation. Experimental inspiratory loading in normal subjects elicits respiratory-related cortical activity during wakefulness. The objective of this study is to test whether awake OSAS patients would exhibit a similar cortical activity. Whether or not such cortical compensatory mechanisms have cognitive consequences would be also analyze.

Details
Condition Obstructive Sleep Apnea Syndrome
Treatment Functional Magnetic Resonance Imaging
Clinical Study IdentifierNCT05147649
SponsorCHU de Reims
Last Modified on26 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

OSAS patients
severe OSAS with an Apnea-Hypopnea Index (AHI) > 30/h
without CPAP treatment
Non-OSAS patients
absence of OSAS (AHI < 15/h and absence of excessive daytime sleepiness with Epworth score <11)
Non-inclusion criteria
< 18 years old
>75 years old
left-handed
BMI> 40 kg/m²
another sleep disorder
central component of sleep apnea syndrome (central apnea index> 5 / h)
current or past neurological pathology
respiratory pathology (obstructive ventilatory disorder, restrictive ventilatory disorder, hypercapnia)
MRI contraindication (metallic foreign body, claustrophobia, pregnant woman, etc.)
taking drugs that can modify the BOLD signal on MRI (psychotropic drugs, vasodilators, vasoconstrictors, etc.)
uncorrected sensory impairment (vision or hearing)
protected by law

Exclusion Criteria

pregnant woman according to the positive beta-hCG test result
left-handed following the laterality questionnaire
MINI results showing
a current mood episode
a current disorder of the use of psychoactive substances or in the last 6 months (excluding tobacco)
an eating disorder
a diagnosis of bipolar disorder, current or past schizophrenia
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