Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome (IRM SAOS)

  • End date
    Feb 26, 2023
  • participants needed
  • sponsor
    CHU de Reims
Updated on 26 May 2022
sleep disorder
obstructive sleep apnea
apnea-hypopnea index
Accepts healthy volunteers


The obstructive sleep apnea syndrome (OSAS) involves recurrent sleep-related upper airways (UA) collapse. UA mechanical properties and neural control are altered, imposing a mechanical load on inspiration. UA collapse does not occur during wakefulness, hence arousal-dependent compensation. Experimental inspiratory loading in normal subjects elicits respiratory-related cortical activity during wakefulness. The objective of this study is to test whether awake OSAS patients would exhibit a similar cortical activity. Whether or not such cortical compensatory mechanisms have cognitive consequences would be also analyze.

Condition Obstructive Sleep Apnea Syndrome
Treatment Functional Magnetic Resonance Imaging
Clinical Study IdentifierNCT05147649
SponsorCHU de Reims
Last Modified on26 May 2022


Yes No Not Sure

Inclusion Criteria

OSAS patients
severe OSAS with an Apnea-Hypopnea Index (AHI) > 30/h
without CPAP treatment
Non-OSAS patients
absence of OSAS (AHI < 15/h and absence of excessive daytime sleepiness with Epworth score <11)
Non-inclusion criteria
< 18 years old
>75 years old
BMI> 40 kg/m²
another sleep disorder
central component of sleep apnea syndrome (central apnea index> 5 / h)
current or past neurological pathology
respiratory pathology (obstructive ventilatory disorder, restrictive ventilatory disorder, hypercapnia)
MRI contraindication (metallic foreign body, claustrophobia, pregnant woman, etc.)
taking drugs that can modify the BOLD signal on MRI (psychotropic drugs, vasodilators, vasoconstrictors, etc.)
uncorrected sensory impairment (vision or hearing)
protected by law

Exclusion Criteria

pregnant woman according to the positive beta-hCG test result
left-handed following the laterality questionnaire
MINI results showing
a current mood episode
a current disorder of the use of psychoactive substances or in the last 6 months (excluding tobacco)
an eating disorder
a diagnosis of bipolar disorder, current or past schizophrenia
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note