Phase I Evaluation of Two Zika Viruses for Use in Controlled Human Infection Models (CHIM)

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Updated on 9 December 2021
Accepts healthy volunteers


This research study will test one of 2 different Zika viruses (ZIKV) so we can find a ZIKV we can safely give to people in the future to test vaccines. 

If you join, you will have one or more screening visits.  If you are healthy and your labs are normal, you will be invited to enroll in the study.  You will get the shot with one of the two versions of the ZIKV or placebo. You will stay in a research inpatient unit for 16 days (or longer) and will have 11 (30-60 minutes) outpatient visits. During the study, we will frequently check you for side effects and illness.  We will check your blood, urine, CVS and saliva for ZIKV.

For taking part in this research, you may be paid up to a total of $5025. 


For more information please call 410-955-7283 or visit

Condition Johns Hopkins CIR is recruiting for a paid inpatient study for Zika, Center for Immunization Research, Inpatient Studies, Vaccines, Paid Studies in Baltimore, Healthy Volunteers Needed for Paid Inpatient Study at Johns Hopkins in Baltimore, Johns Hopkins, CIR, Paid research studies near me, Healthy Volunteers, *Healthy Patient Studies
Clinical Study IdentifierTX289028
Last Modified on9 December 2021


Yes No Not Sure

Inclusion Criteria

Healthy non-pregnant females
18-40 years old
No previous history of flavivirus infection
Available for the duration of the study (approximately 26 weeks post-inoculation)
Willing to use barrier contraception
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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