Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cells for the Treatment of Eye Diseases

  • End date
    Jan 22, 2026
  • participants needed
  • sponsor
    The Foundation for Orthopaedics and Regenerative Medicine
Updated on 22 October 2022
brimonidine tartrate ophthalmic solution
other disease
eye disease


This trial will study the safety and efficacy of intravenous and sub-tenon delivery of cultured allogeneic adult umbilical cord derived mesenchymal stem cells for the treatment of Eye diseases


This patient funded trial aims to study the safety and efficacy of intravenous and sub-tenon delivery of cultured allogeneic adult umbilical cord derived mesenchymal stem cells (UC-MSCs) for the treatment of Eye Diseases. The total dose will be 100 million cells. Patients will be evaluated within one month pre treatment and at 1, 6, 12, 24, 36, and 48 months post treatment for safety and efficacy.

Condition Eye Diseases, Retinitis Pigmentosa, Glaucoma, Diabetic Retinopathy, Macular Degeneration, Traumatic Optic Neuropathy, Optic Atrophy
Treatment AlloRx
Clinical Study IdentifierNCT05147701
SponsorThe Foundation for Orthopaedics and Regenerative Medicine
Last Modified on22 October 2022


Yes No Not Sure

Inclusion Criteria

Diagnosis of eye disease
Understanding and willingness to sign a written informed consent document

Exclusion Criteria

Active infection
Active cancer
Chronic multisystem organ failure
Clinically significant Abnormalities on pre-treatment laboratory evaluation
Medical condition that would (based on the opinion of the investigator) compromise patient's safety
Continued drug abuse
Pre-menopausal women not using contraception
Previous organ transplant
Hypersensitivity to sulfur
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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