A Phase 3, Randomized, Double-blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab in Adult Participants Who Have Thrombotic Microangiopathy Associated With a Trigger

  • STATUS
    Not Recruiting
  • End date
    Dec 31, 2025
  • participants needed
    100
  • sponsor
    Alexion Pharmaceuticals
Updated on 20 October 2022

Summary

This study will investigate the efficacy and safety of ravulizumab compared to placebo in adult participants with thrombotic microangiopathy (TMA) associated with a trigger. Participants will be randomized to receive either ravulizumab plus best supportive care or placebo plus best supportive care. The treatment period is 26 weeks followed by a 26-week off-treatment follow-up period.

Details
Condition Thrombotic Microangiopathy
Treatment Placebo, Best supportive care, Ravulizumab
Clinical Study IdentifierNCT04743804
SponsorAlexion Pharmaceuticals
Last Modified on20 October 2022

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