A Phase 3, Randomized, Double-blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab in Adult Participants Who Have Thrombotic Microangiopathy Associated With a Trigger

    Not Recruiting
  • End date
    Dec 31, 2025
  • participants needed
  • sponsor
    Alexion Pharmaceuticals
Updated on 20 October 2022


This study will investigate the efficacy and safety of ravulizumab compared to placebo in adult participants with thrombotic microangiopathy (TMA) associated with a trigger. Participants will be randomized to receive either ravulizumab plus best supportive care or placebo plus best supportive care. The treatment period is 26 weeks followed by a 26-week off-treatment follow-up period.

Condition Thrombotic Microangiopathy
Treatment Placebo, Best supportive care, Ravulizumab
Clinical Study IdentifierNCT04743804
SponsorAlexion Pharmaceuticals
Last Modified on20 October 2022

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