Management of Oxaliplatin-related Gastroesophageal Variceal Bleeding
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- STATUS
- Recruiting
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- End date
- Dec 31, 2023
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- participants needed
- 100
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- sponsor
- Shanghai Zhongshan Hospital
Summary
In this randomized controlled study, we aim to compare the efficacy and safety of these two interventions in patients with oxaliplatin-induced gastroesophageal variceal bleeding.
Description
Oxaliplatin is used as the first-line chemotherapy for colorectal cancer. However, oxaliplatin-induced hepatotoxicity could lead to sinusoidal injury and portal hypertension in the long term. Variceal bleeding, as the most common complication of portal hypertension, threaten these patents' life. Endoscopic treatment and Transjugular Intrahepatic Portosystemic Shunt (TIPS) are both recommended management of gastroesophageal variceal bleeding. In this randomized controlled study, we aim to compare the efficacy and safety of these two interventions in patients with oxaliplatin-induced gastroesophageal variceal bleeding.
Details
| Condition | Gastrointestinal Neoplasm, gastrointestinal cancer, Gastroesophageal Varices Hemorrhage, gastrointestinal cancers, Digestive System Neoplasms, Neoplasm of unspecified nature of digestive system, GASTROINTESTINAL DISORDER, Gastrointestinal Diseases and Disorders, Received Oxaliplatin-based Chemotherapy |
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| Treatment | TIPS, Endoscopic treatment |
| Clinical Study Identifier | NCT05141617 |
| Sponsor | Shanghai Zhongshan Hospital |
| Last Modified on | 9 December 2021 |
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