Chidamide Combines With VP-16 and Methylprednisolone in the Treatment of HLH

  • STATUS
    Recruiting
  • End date
    Jul 1, 2023
  • participants needed
    20
  • sponsor
    Beijing Friendship Hospital
Updated on 5 December 2021

Summary

Chidamide combines with VP-16 and methylprednisolone in HLH

Description

This study aimed to investigate the efficacy and safety of Chidamide together with Etoposide and methylprednisolone for hemophagocytic lymphohistiocytosis

Details
Condition Chidamide, Hemophagocytic lymphohistiocytosis
Treatment Chidamide combines with VP-16 and methylprednisolone
Clinical Study IdentifierNCT05137522
SponsorBeijing Friendship Hospital
Last Modified on5 December 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Meet hemophagocytic lymphohistiocytosis (HLH)-04 diagnostic
criteria; patients were diagnosed with EBV associated HLH (EBV-HLH) and
lymphoma associated HLH.Age 18 years old, gender is not limited. Serum
creatinine 1.5 times normalNT-proBNP normalInformed consent obtained
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Exclusion Criteria

Active bleeding of the internal organs or patients with
new thrombotic diseasesAllergic to Chidamide and etoposideParticipate in other
clinical research at the same timeHIV , HBV and HCV infected patients (HIV
antibody positive)History of QT interval prolongation, atrioventricular block
ventricular tachycardia, coronary atherosclerotic heart diseasePregnant or
lactating women and patients of childbearing age who refuse to take
appropriate contraceptive measures during this trial. If the patient was male
he refused to use adequate contraceptive methods or donate semen during the
study period and within 3 months after receiving the last cycle of drug
studypatients judged by the investigator to be unsuitable to participate in
this study
\-
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