A Study of CIN-107 in Patients With Uncontrolled Hypertension Receiving 1 Antihypertensive Agent (HALO)

  • STATUS
    Recruiting
  • days left to enroll
    72
  • participants needed
    212
  • sponsor
    CinCor Pharma, Inc.
Updated on 23 April 2022

Summary

This is a Phase 2, randomized, multicenter study to evaluate the efficacy and safety of multiple dose strengths of CIN-107 in the treatment of patients with uncontrolled hypertension who are currently taking 1 anti-hypertensive medication

Details
Condition Uncontrolled Hypertension
Treatment Placebo, CIN-107
Clinical Study IdentifierNCT05137002
SponsorCinCor Pharma, Inc.
Last Modified on23 April 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Is on a stable regimen of a single background antihypertensive agent for at least 8 weeks and a second antihypertensive agent is warranted at the time of screening
Has a mean seated systolic blood pressure (SBP) ≥ 140 mmHG
Demonstrates they are able to be adherent to the study drug and their anti-hypertensive medication during a run-in period
If taking SGLT2 inhibitor, the regimen must be stable for at least 8 weeks prior to randomization; and
Agrees to comply with the contraception and reproduction restrictions of the study

Exclusion Criteria

Has a mean seated systolic blood pressure (SBP) ≥180 mmHG
Has a body mass index (BMI) >50 kg/m2
Is using alpha or beta blockers for any primary indication other than systemic hypertension (eg, migraine headache)
Is not willing or not able to discontinue an MRA or potassium sparing diuretic as part of an existing antihypertensive regimen
Has documented estimated eGFR <30 mL/min/1.73m2
Has known and documented New York Heart Association stage III or IV chronic heart failure
Has had a stroke, transient ischemic attack, hypertensive encephalopathy, acute coronary syndrome, or hospitalization for heart failure within 6 months before screening
Major cardiac surgery within 6 months before Screening
Has chronic permanent atrial fibrillation
Has uncontrolled diabetes with glycosylated hemoglobin >10% at Screening
Has planned dialysis or kidney transplantation planned during the course of the study
Prior solid organ transplant and/or cell transplants
Sodium <130 mEq/L
Potassium <3.5 mEq/L
Potassium >5 mEq/L
Is positive for HIV antibody, hepatitis C virus RNA, or hepatitis B surface antigen
Has typical consumption of ≥14 alcoholic drinks weekly
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact

site

0/250

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Loading...

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 

 • 

Private

Reply by • Private
Loading...

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.
Loading...

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note