Comparison of Posterior Continuous Curvilinear Capsulorhexis With or Without Anterior Vitrectomy

  • STATUS
    Recruiting
  • End date
    Nov 1, 2026
  • participants needed
    50
  • sponsor
    Sun Yat-sen University
Updated on 6 December 2021

Summary

Selecting the appropriate surgical approach for congenital cataracts presents challenging for ophthalmologists. This prospective, randomized controlled study aims to compare the prognosis of posterior continuous curvilinear capsulorhexis (PCCC) with or without anterior vitrectomy (A-Vit) in treating congenital cataracts.

Description

Due to the particularity of children's eye structure, selecting the appropriate surgical approach for congenital cataracts presents challenging for ophthalmologists. The major concerned postoperative problem is the after-cataract formation. As a result, PCCC with A-Vit is usually performed to prevent the formation of secondary cataracts. However. Debate over the indication and surgical procedure still persists since A-Vit and excessive manipulations may interfere with the development of the eye and increase the risk of postoperative inflammation, unstable intraocular pressure, macular edema, retinal detachment and so on. Thus, it is necessary to evaluate the safety and effectiveness of PCCC without A-Vit in congenital cataract surgery.

In this randomized clinical trial, children with equal degree of congenital cataract in both eyes are enrolled. Patients receive cataract surgery on both eyes on the same day. For each patient, one eye is randomly assigned to undergo PCCC+A-Vit procedure, while the fellow eye is undergoing PCCC procedure without A-Vit. PCCC+A-Vit procedure includes anterior continuous curvilinear capsulorhexis (ACCC), irrigation/aspiration (I/A), PCCC, and A-Vit. Primary intraocular lens implantation (IOL) is performed in children older than age of two. Investigators then compare the incidence of visual axis opacity, uveitis, iris/pupil abnormality and intraocular pressure between two groups.

Details
Condition Congenital Cataract, congenital cataracts
Treatment PCCC procedure without A-vit, PCCC+A-Vit procedure
Clinical Study IdentifierNCT05136209
SponsorSun Yat-sen University
Last Modified on6 December 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Children with bilateral congenital cataracts without other ocular abnormalities
Gestational age at birth >37 weeks
No more than 18 years old
Pupils could dilate normally pre-operation
Have signed a consent form
Can be followed

Exclusion Criteria

Intraocular pressure >21 mmHg
History of ocular trauma and intraocular surgery
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