Helicobacter Pylori First-line Treatment Containing Tetracycline in Patients Allergic to Penicillin

  • STATUS
    Recruiting
  • days left to enroll
    34
  • participants needed
    106
  • sponsor
    Shandong University
Updated on 3 December 2021

Summary

The purpose of this study is to assess and compare the effectiveness of levofloxacin-tetracycline -containing and metronidazole-tetracycline-containing quadruple regimens for the primary treatment of Helicobacter pylori infection in patients allergic to penicillin.

Description

Helicobacter pylori(H.pylori), which infects about 50% of the global population, has been recognized as a main risk factor of multiple gastric pathologies, especially non-cardiac gastric cancer. Strongly evidence supports that H.pylori eradication is an effective approach to reduce the incidence of those pathologies.However,Helicobacter pylori eradication is a challenge in patients allergic to penicillin. Therefore, the investigators aim to assess and compare the effectiveness of levofloxacin-tetracycline -containing and metronidazole-tetracycline-containing quadruple regimens for the primary treatment of Helicobacter pylori infection in patients allergic to penicillin.

Details
Condition Helicobacter Pylori Infection, H. Pylori Infection
Treatment levofloxacin, metronidazole
Clinical Study IdentifierNCT05129176
SponsorShandong University
Last Modified on3 December 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients aged 18-70 with H. pylori infection
Patients Allergic to Penicillin

Exclusion Criteria

Patients with previous H. pylori eradication therapy
Patients treated with Histamine-receptor antagonist, proton pump inhibitor, bismuth and antibiotics in the previous 4 weeks
Patients with gastrectomy, acute gastrointestinal bleeding and advanced gastric cancer
Patients with known or suspected allergy to study medications
Currently pregnant or lactating
Inability to provide informed consent
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