Gas Exchange Derangement Physiopathology in Critically Ill Patients With COVID-19

  • STATUS
    Recruiting
  • days left to enroll
    88
  • participants needed
    14
  • sponsor
    Policlinico Hospital
Updated on 1 December 2021
mechanical ventilation
respiratory distress
FIO2
positive end expiratory pressure
assisted ventilation
acute respiratory distress syndrome

Summary

The study was designed to understand the pathophysiology of gas exchange derangement in critically ill patients with COVID-19. Specifically we will evaluate the effect of 3 different levels of positive end-expiratory pressure (PEEP) and two different levels of inspiratory oxygen fraction (FiO2) on gas exchange by analyzing shunt and dead space. Furthermore, complete respiratory mechanics and distribution of ventilation and perfusion by electrical impedance tomography will be assessed at each level of PEEP.

Details
Condition Respiratory Failure
Treatment PEEP trial - Electrical Impedance Tomography
Clinical Study IdentifierNCT05132933
SponsorPoliclinico Hospital
Last Modified on1 December 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients admitted in intensive care unit for COVID-19 related Acute Respiratory Distress Syndrome (ARDS) requiring invasive mechanical ventilation

Exclusion Criteria

Pregnancy
Hemodynamic instability (80-90 mmHg increase or 30-40 mmHg decrease systolic arterial pressure compared to baseline value or need of vasopressors to maintain systolic blood pressure higher than 85 mmHg or electrocardiogram evidence of ischemia/arrhythmias)
Presence of pneumothorax and/or pneumomediastinum
Contraindications to Electrical Impedance Tomography (pacemaker, implantable cardioverter defibrillator, thoracic drainages)
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