Pharmacokinetics of Piperacillin and Meropenem in ICU Patients

  • End date
    Dec 31, 2023
  • participants needed
  • sponsor
    Karolinska University Hospital
Updated on 2 December 2021


The purpose of the study is to characterize the pharmacokinetics of meropenem and piperacillin in ICU-patients at the time of the first dose administration and to contrast that with the same measurements obtained in the same patient 2-3 days later during the course of ICU treatment.

Condition Antibiotic Pharmacokinetics
Treatment Piperacillin/tazobactam, Meropenem
Clinical Study IdentifierNCT05134298
SponsorKarolinska University Hospital
Last Modified on2 December 2021


Yes No Not Sure

Inclusion Criteria

Patient being treated in one of the participating ICUs and planned to recieve treatment with meropenem or piperacillin
Exclusion Criteria (fullfilling any exlusion criteria means that patient
cannot be included in the study)
Not possible to retrospectively ask the patient or next of kin for consent to take part in the study or patient or next-of-kin not providing consent
Not posisble to obtain and process blood samples as specified by protocol
Ongoing renal replacement therapy
Patient having received the same antibiotic within the previous 96 h
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