Natural History of COVID-19-Related Atrial Fibrillation

  • STATUS
    Recruiting
  • End date
    Dec 31, 2023
  • participants needed
    200
  • sponsor
    Texas Cardiac Arrhythmia Research Foundation
Updated on 29 November 2021

Summary

The unCOVer-AF prospective, multicenter registry aims at determining the natural history of atrial fibrillation (AF) via continuous cardiac rhythm monitoring in patients with a first arrhythmic episode during COVID-19 hospitalization.

Description

Coronavirus Disease 2019 (COVID-19) is a novel coronavirus strain disease, which has rapidly spread worldwide with more than 100 million confirmed cases to date. COVID-19 is mainly characterized by respiratory symptoms; however, patients can exhibit a wide range of clinical manifestations, including cardiovascular complications. Among them, supraventricular and ventricular arrhythmias have been described in patients at different stages of disease severity. According to a recent study on 9564 COVID-19 patients, 17.6% developed AF during hospitalization, 65.7% of whom without a past arrhythmic history.

Several factors (e.g., hypoxia, systemic inflammatory response, myocardial injury) may interact with a preexisting substrate and act as a trigger for AF initiation. Nonetheless, the pathophysiology of COVID-19-related new-onset AF remains elusive. It is unknown whether the disease merely acts as a transient arrhythmia initiator or promotes long-term atrial electrophysiological and structural changes which may facilitate AF recurrence and progression.

Therefore, the investigators designed a multicenter, prospective registry to assess the natural history of AF via continuous cardiac rhythm monitoring (ILR, PMK, ICD) in patients with a first AF episode during COVID-19 hospitalization.

Details
Condition Atrial Fibrillation New Onset, *COVID-19, Covid-19
Treatment ILR, PMK, ICD
Clinical Study IdentifierNCT04830774
SponsorTexas Cardiac Arrhythmia Research Foundation
Last Modified on29 November 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Age> 18 years
Confirmed infection with SARS-CoV-2
Patients with a first clinical episode of AF 30 s at admission or during hospitalization for COVID-19
Patients with
implantation of an ILR, a PMK, or an ICD during COVID-19 hospitalization or within 30 days after hospital discharge, or
an ILR, a PMK, or an ICD implanted before COVID-19 hospitalization

Exclusion Criteria

History of AF or flutter irrespective of type
Moderate/severe mitral stenosis
Mechanical prosthetic heart valve(s)
Kidney failure treated with permanent dialysis
Any condition (e.g. psychiatric illness, dementia) or situation, that in the investigators opinion could put the subject at significant risk, confound the study results, or interfere significantly with the subject participation in the study
Unwillingness to participate
Clear my responses

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