Natural History of COVID-19-Related Atrial Fibrillation
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- STATUS
- Recruiting
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- End date
- Dec 31, 2023
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- participants needed
- 200
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- sponsor
- Texas Cardiac Arrhythmia Research Foundation
Summary
The unCOVer-AF prospective, multicenter registry aims at determining the natural history of atrial fibrillation (AF) via continuous cardiac rhythm monitoring in patients with a first arrhythmic episode during COVID-19 hospitalization.
Description
Coronavirus Disease 2019 (COVID-19) is a novel coronavirus strain disease, which has rapidly spread worldwide with more than 100 million confirmed cases to date. COVID-19 is mainly characterized by respiratory symptoms; however, patients can exhibit a wide range of clinical manifestations, including cardiovascular complications. Among them, supraventricular and ventricular arrhythmias have been described in patients at different stages of disease severity. According to a recent study on 9564 COVID-19 patients, 17.6% developed AF during hospitalization, 65.7% of whom without a past arrhythmic history.
Several factors (e.g., hypoxia, systemic inflammatory response, myocardial injury) may interact with a preexisting substrate and act as a trigger for AF initiation. Nonetheless, the pathophysiology of COVID-19-related new-onset AF remains elusive. It is unknown whether the disease merely acts as a transient arrhythmia initiator or promotes long-term atrial electrophysiological and structural changes which may facilitate AF recurrence and progression.
Therefore, the investigators designed a multicenter, prospective registry to assess the natural history of AF via continuous cardiac rhythm monitoring (ILR, PMK, ICD) in patients with a first AF episode during COVID-19 hospitalization.
Details
| Condition | Atrial Fibrillation New Onset, *COVID-19, Covid-19 |
|---|---|
| Treatment | ILR, PMK, ICD |
| Clinical Study Identifier | NCT04830774 |
| Sponsor | Texas Cardiac Arrhythmia Research Foundation |
| Last Modified on | 29 November 2021 |
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