Acylcarnitine Profile After Intensive Care

  • STATUS
    Recruiting
  • days left to enroll
    67
  • participants needed
    100
  • sponsor
    University of Liege
Updated on 1 December 2021

Summary

The aim of the study is to compare the acylcarnitine profile of critically ill survivors of a prolonged stay in ICU with the profile of survivors of short ICU length of stay. The second aim is to assess the evolution of the acylcarnitine profile over time in survivors of a prolonged ICU stay.

Description

In a retrospective analysis focused on survivors of an ICU stay of 7 days or more, we showed that during the week following discharge, carnitine deficiency was rare, but acylcarnitine profile was altered, with an abnormal acylcarnitine/carnitine ratio in more than 25% of the population.

Carnitine has a key role in cellular energy metabolism and is a a biomarker of the mitochondria function. Moreover, mitochondrial function is proven to be severely impaired in critically ill patients and mitochondrial dysfunction has been linked to post-ICU disorders.

In this context, it is relevant to study the evolution over time of the acylcarnitine profile in ICU survivors of a prolonged ICU stay. It is also relevant to compare the same profile between survivors of a prolonged and a shorter ICU stay.

Details
Condition Critical Care, Carnitine Metabolism Disturbances
Treatment Serum acylcarnitine profiling
Clinical Study IdentifierNCT05115734
SponsorUniversity of Liege
Last Modified on1 December 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Group short stayers: ICU length of stay of 2 days
Group long stayers: ICU length of stay of at least 7 days

Exclusion Criteria

patient refusal
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