NTLA-2002 in Adults With Hereditary Angioedema (HAE) (NTLA-2002)

  • End date
    Dec 15, 2025
  • participants needed
  • sponsor
    Intellia Therapeutics
Updated on 4 October 2022


This study will be conducted to evaluate the safety, tolerability, activity, pharmacokinetics, and pharmacodynamics of NTLA-2002 in adults with Hereditary Angioedema (HAE).

Condition Hereditary Angioedema
Treatment Biological NTLA-2002, Normal Saline IV Administration
Clinical Study IdentifierNCT05120830
SponsorIntellia Therapeutics
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

Age >18 years
Diagnosis of HAE Types I or II
Ability to provide evidence of HAE attacks to meet the screening requirement
Subjects must have access to, and the ability to use, ≥ 1 acute medication(s) to treat angioedema attacks
Adequate chemistry and hematology measures at screening
Subjects must agree not to participate in another interventional study for the duration of this trial
Subjects must be capable of providing signed informed consent

Exclusion Criteria

Concurrent diagnosis of any other type of recurrent angioedema
Subjects who have known negative reaction or hypersensitivity to any lipid nanoparticles (LNP) component
Any condition that, in the Investigator's opinion, could adversely affect the safety of the subject
Unwilling to comply with study procedures
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What happens next?
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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