Effect of Milrinone Versus Placebo on Hemodynamics in Patients With Septic Shock; Randomized Control Trial
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- STATUS
- Recruiting
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- End date
- Jun 18, 2025
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- participants needed
- 64
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- sponsor
- Mahidol University
Summary
Sepsis is one of the most serious healthcare problems, worldwide, and financial burdens.
The overall mortality of severe sepsis/septic shock was 44.5-52.6%. A common cause of death is refractory shock and multi-organ failure. Myocardial dysfunction is a relatively common complication of septic shock. This causes a decrease in the amount of cardiac output, resulting in insufficient blood supply to the organ and multi-organ failure and lead to death Early goal-directed therapy began to use dobutamine in patients with septic shock Sepsis Survival Campaign Guideline 2016 recommended drug is dobutamine and an alternative drug is milrinone in septic shock patients with clinical signs of poor tissue perfusion.
Description
According to several studies, the use of dobutamine increases the amount of cardiac output but it has also been reported to increase mortality rates too. There are few studies of milrinone in patients with septic shock.
Details
| Condition | Septic Shock, Cardiac Output |
|---|---|
| Treatment | Milrinone |
| Clinical Study Identifier | NCT05122884 |
| Sponsor | Mahidol University |
| Last Modified on | 18 October 2022 |
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