Behavioral Activation and Medication Optimization for Perioperative Mental Health

  • End date
    Mar 31, 2024
  • participants needed
  • sponsor
    Washington University School of Medicine
Updated on 19 January 2022
behavior therapy
depressive symptoms
depressed mood


Inadequate management of preoperative mental health disorders often contributes to poor postoperative outcomes, including increased rates of readmission, delirium, falls, and mortality. However, very little work has been done to improve perioperative mental health. In particular, there has been limited systematic efforts that identify evidence-based behavioral and pharmacological strategies that were originally developed for depression and anxiety in otherwise medically well psychiatric patients. A mental health intervention bundle, composed of behavioral and pharmacological strategies, can mitigate anxiety and depression symptoms during the perioperative period. However, lacking is conclusive evidence on effectiveness of such an intervention bundle focused on the delivery of perioperative mental health care in older surgical patients. Towards this end, the investigators will develop and test an intervention bundle that encompasses: (1) behavioral activation, and (2) medication optimization.


The proposed research is relevant to public health because the prevalence of undertreated depression/anxiety in older adults coupled with the increasing number of surgeries performed in this population are creating a crucial need for the integration of mental health interventions into critical periods, such as the perioperative period. Thus, the proposed research is relevant to the mission of the NIMH to transform the treatment of mental illnesses through clinical research, paving the way for prevention, recovery, and cure.

Condition Anxiety Disorders, Generalized Anxiety Disorder (GAD - Pediatric), Older Adults, depressive disorder, ANXIETY NEUROSIS, miserable, Depression (Major/Severe), orthopedic surgeries, Endogenous depression, heart surgery, depressive disorders, anxious, Depressed, Thoracic Surgery, Depression (Adolescent), Cardiac Surgery, depressed mood, Orthopedics, anxiety disorder, Anxiety, Depression, cardiac operation, Major Surgical Resection of a Thoracic Malignancy, Major Surgical Resection of a Abdominal Malignancy, Generalized Anxiety Disorder (GAD), Depression (Pediatric), Anxiety Disorders (Pediatric), Anxiety Symptoms, Depression (Treatment-Resistant), Depression (Adult and Geriatric), Orthopaedic procedure NOS, Orthopedic Surgery
Treatment Behavioral Activation, Medication Optimization, Medication Optimization
Clinical Study IdentifierNCT05110690
SponsorWashington University School of Medicine
Last Modified on19 January 2022


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